2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991169
    Zemocimig 2955620-21-8 98%
    Zemocimig is an anti-coagulation factor F9 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    Zemocimig
  • HY-P991210
    Efzimfotase alfa 2746354-58-3 98%
    Efzimfotase alfa (ALXN-1850) is enzyme replacement therapy agent targeting the deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa functions by hydrolyzing the substrates of TNSALP, reducing the concentrations of substrates such as inorganic pyrophosphate (PPi) and pyridoxal 5′-phosphate (PLP). Efzimfotase alfa is promising for research of hypophosphatasia (HPP).
    Efzimfotase alfa
  • HY-P991211
    Bemiltenase alfa 2766038-73-5 98%
    Bemiltenase alfa is a hemostatic agent targeting coagulation factor X (FX). Bemiltenase alfa activates FX and promotes the conversion of prothrombin to thrombin, and thrombin can further transform fibrinogen into fibrin, forming a stable blood clot, thus exerting hemostatic activity. Bemiltenase alfa is promising for research of bleeding symptoms with hemophilia.
    Bemiltenase alfa
  • HY-P991213
    Nonacog gamma 98%
    Nonacog gamma is a coagulation factor IX (FIX) supplement. Nonacog gamma activates coagulation factor X (FX), promotes the generation of thrombin, and then converts fibrinogen into fibrin, forming a stable blood clot to exert hemostatic activity. Nonacog gamma is promising for research of hemophilia B.
    Nonacog gamma
  • HY-P991333
    GSK-315234 98%
    GSK-315234 is a human IgG1 monoclonal antibody (mAb) targeting OSM . GSK-315234 can be used in the study of atherosclerosis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    GSK-315234
  • HY-P991340
    CT140 98%
    CT140 is a human IgG4 monoclonal antibody (mAb) targeting PAI-1. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).
    CT140
  • HY-P991411
    NI-006
    NI-006 (ALXN2220) is a human monoclonal antibody (mAb) targeting Transthyretin/TTR. NI-006 stimulates macrophage-mediated phagocytosis of deposited amyloid fibrils. NI-006 can be used in Cardiomyopathies and Familial amyloid neuropathy research.
    NI-006
  • HY-P991412
    NI-301
    NI-301 is a human monoclonal antibody (mAb) targeting Transthyretin/TTR. NI-301 can be used in Cardiomyopathies and Familial amyloid neuropathy research.
    NI-301
  • HY-P991422
    Stromab
    Stromab (DS9231; TS-23; CSL-301) is a human IgG1 monoclonal antibody (mAb) targeting Serpin F2. Stromab can be used in schaemic stroke, Pulmonary embolism, Myocardial infarction and Thrombosis research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992).
    Stromab
  • HY-P991474
    TATX-21
    TATX-21 is a human monoclonal antibody (mAb) targeting ACVRL1/ALK-1. TATX-21 can be used in arterial sclerosis and heart disease research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    TATX-21
  • HY-U00049A
    Mioflazine (di(hydrochloride) hydrate) 79467-24-6 98%
    Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig.
    Mioflazine (di(hydrochloride) hydrate)
  • HY-U00049B
    Mioflazine di(hydrochloride) 83898-67-3 98%
    Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing.
    Mioflazine di(hydrochloride)
  • HY-W009027
    Indoramin hydrochloride 38821-52-2 98%
    Indoramin (hydrochloride) is a new hypotensive agent. Indoramin (hydrochloride) is also selective for the α1A-adrenoceptor.
    Indoramin hydrochloride
  • HY-W011231
    DHP-050 74936-72-4 98%
    DHP-050 is a Felodipine (HY-B0309) analog. DHP-050 can be used to study the structure-activity relationship of 1,4-dihydropyridine (DHP) compounds.
    DHP-050
  • HY-W011269
    Eicosapentaenoic Acid sodium 73167-03-0 98%
    Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation.
    Eicosapentaenoic Acid sodium
  • HY-W012159
    Methionylserine 14517-43-2 98%
    Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension.
    Methionylserine
  • HY-W014726
    DL-Phenylephrine hydrochloride 154-86-9 98%
    DL-Phenylephrine ((±)-Phenylephrine) hydrochloride is a selective agonist of the alpha1-adrenergic receptor, exhibiting potent vasoconstrictive activity.
    DL-Phenylephrine hydrochloride
  • HY-W016733
    D-Citrulline 13594-51-9 ≥98.0%
    D-Citrulline (H-D-Cit-OH) is a stereoisomer of L-citrulline (HY-N0391). D-Citrulline significantly attenuates polymorphonuclear leukocyte (PMN)-induced cardiac contractile dysfunction in the isolated perfused rat heart subjected to ischemia/reperfusion via a non-NO-mediated mechanism.
    D-Citrulline
  • HY-W019878
    β-Endorphin, rat 59887-17-1 98%
    β-Endorphin, rat (β-Lipotropin 61-91), a neuropeptide, is involved in cardiovascular regulation. β-Endorphin, rat induces marked, prolonged muscular rigidity and immobility similar to a catatonic state in rats.
    β-Endorphin, rat
  • HY-W091169
    N-Methyl-2-HOBA hydrochloride 63989-87-7 98%
    N-Methyl-2-HOBA (2-((Methylamino)methyl)phenol) hydrochloride is a methylated form of the isoketal scavenger 2-HOBA (HY-34350). N-Methyl-2-HOBA hydrochloride can be used as a negative control for the activity of 2-HOBA in a mouse model of hypertension.
    N-Methyl-2-HOBA hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity